Porphyrin Biosynthesis. 5. Biosynthesis of Protoporphyrin IX in Harderian Glands
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چکیده
منابع مشابه
Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia
5-Aminolevulinic acid (ALA), a precursor of porphyrin, is specifically converted to the fluorescent substance protoporphyrin IX (PpIX) in tumors to be used as a prodrug for photodynamic therapy and diagnosis. Hypoxia, a common feature of solid tumors, decreases the efficacy of ALA-based photodynamic therapy and diagnosis. This decrease results from the excretion of porphyrin precursor coproporp...
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The porphyrinogens are colorless, reduced porphyrins containing 6 extra atoms of hydrogen. They have been reported to occur in biological materials by Fischer, who isolated COPRO’gen’ from the feces of his porphyria patient Petry (l), and by Watson, Schwartz, and coworkers, who showed that COPRO’gen was present in the urine of some of their patients with various porphyrias (2). Suspicions that ...
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Bovine liver mitochondria have been found to contain an enzyme which will catalyze the formation of &aminolevulinic acid via a transamination reaction rather than via the condensation of glycine and succinyl coenzyme A. The enzyme, L-alanine:y,bdioxovaleric acid aminotransferase (y,&dioxovalerate transaminase) was isolated and purified to apparent homogeneity. y,&Dioxovalerate transaminase is q...
متن کاملRegulation of Porphyrin Biosynthesis
6-Aminolevulinic acid synthase has been purified 1300-fold from photosynthetically cultured Rhodopseudomonas spheroides. The enzyme having a specific activity of 130 units per mg shows one major band and two minor bands upon disc electrophoresis. Some properties, including molecular weight, stability, and the inhibition of enzyme activity by hemin are reported. The comparative behavior of crude...
متن کاملMagnesium protoporphyrin monoester and protoporphyrin monomethyl ester in chlorophyll biosynthesis.
In previous studies on Chlorella mutants, several compounds were isolated which were postulated to be intermediates in chlorophyll synthesis. Protoporphyrin-9 was identified as the main porphyrin product from one mutant (I), magnesium protoporphyrin was found in another mutant (a), and magnesium vinylpheoporphyrin a5 in a third (3). Here we report on the isolation and identification of magnesiu...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1968
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1968.tb00421.x